癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CaBP7 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | Q86V35 |
| Other Accession | NP_872333, 32698884 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 24453 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | CaBP7 antibody can be used for detection of CaBP7 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 4 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 164633 |
|---|---|
| Other Names | Calcium-binding protein 7, CaBP7, Calneuron II, Calneuron-2, CABP7, CALN2 |
| Target/Specificity | CABP7; |
| Reconstitution & Storage | CaBP7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | CaBP7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CABP7 |
|---|---|
| Synonyms | CALN2 |
| Function | Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CaBP7 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
REFERENCES
Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51.
Haeseleer F, Imanishi Y, Sokal I, et al. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem. Biophys. Res. Commun.2002; 290:615-23.
Ikura M, Osawa M, and Ames JB. The role of calcium-binding proteins in the control of transcription: structure to function. Bioessays2002; 24:625-36.
McCue HV, Burgoyne RD, Haynes LP. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun.2009; 380:825-31.
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