癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WDR92 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q96MX6 |
| Other Accession | NP_612467, 24308444 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 39740 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | WDR92 antibody can be used for detection of WDR92 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 116143 |
|---|---|
| Other Names | WD repeat-containing protein 92, WD repeat-containing protein Monad, WDR92 |
| Target/Specificity | WDR92; |
| Reconstitution & Storage | WDR92 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | WDR92 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DNAAF10 (HGNC:25176) |
|---|---|
| Synonyms | WDR92 |
| Function | Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm. |
| Cellular Location | Dynein axonemal particle {ECO:0000250|UniProtKB:A8J3F6} |
| Tissue Location | Widely expressed with the highest expression in testis. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
WDR92 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR92, also known as monad, contains two WD40 repeats is widely expressed in human tissues, especially testis. Overexpression of this protein or its binding partner RNA polymerase II-associated protein 3 (RPAP3) potentiated apoptosis and caspase-3 activation induced by TNF-α and cycloheximide, suggesting that WDR92, together with RPAP3, may function as a novel modulator of apoptosis.
REFERENCES
Saeki M, Irie Y, Ni L, et al. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. Biochem. Biophys. Res. Commun.2006; 342:568-72.
Itsuki Y, Saeki M, Nakahara H, et al. Molecular cloning of novel Monad binding protein containing tetratricorticopeptide repeat domains. FEBS Lett.582:2365-70.
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