癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NALP10 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q86W26 |
| Other Accession | NP_789791, 28827807 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 75032 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | NALP10 antibody can be used for detection of NALP10 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 338322 |
|---|---|
| Other Names | NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8, NLRP10, NALP10, NOD8, PYNOD |
| Target/Specificity | NLRP10; |
| Reconstitution & Storage | NALP10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | NALP10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NLRP10 |
|---|---|
| Synonyms | NALP10, NOD8, PYNOD |
| Function | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti- inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection |
| Tissue Location | Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NALP10 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
REFERENCES
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Wang Y, Hasegawa M, Imamura R, et al. PYNOD,a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Int. Immunol.2004; 16:777-86.
Imamura R, Wang Y, Kinoshita T, et al. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol.2010; 184:5874-84.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
