癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NALP14 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86W24 |
| Other Accession | NP_789792, 28827813 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 124733 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | NALP14 antibody can be used for detection of NALP14 by Western blot at 1 µg/mL. |
| Gene ID | 338323 |
|---|---|
| Other Names | NACHT, LRR and PYD domains-containing protein 14, Nucleotide-binding oligomerization domain protein 5, NLRP14, NALP14, NOD5 |
| Target/Specificity | NLRP14; |
| Reconstitution & Storage | NALP14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | NALP14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NLRP14 |
|---|---|
| Synonyms | NALP14, NOD5 {ECO:0000303|PubMed:1276675 |
| Function | Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (By similarity). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (By similarity). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41951593). Also plays a role in spermatogenesis by regulating differentiation of primordial germ cell-like cells, possibly by protecting HSPA2 from proteasome- mediated degradation (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6B966}. |
| Tissue Location | Testis-specific.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NALP14 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP14 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP14, it has been suggested that it may play a role in spermatogenesis and that mutations in the NALP14 gene might cause spermatogenic failure.
REFERENCES
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Westerveld GH, Korver CM, van Pelt AMM, et al. Mutations in the tesits-specific NALP14 gene in men suffering from spermatogenic failure. Hum. Reprod.2006; 21:3178-84.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
