癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MFSD1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E, IHC-P |
|---|---|
| Primary Accession | Q9H3U5 |
| Other Accession | NP_073573, 269847416 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 51209 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | MFSD1 antibody can be used for detection of MFSD1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. |
| Gene ID | 64747 |
|---|---|
| Other Names | Major facilitator superfamily domain-containing protein 1, Smooth muscle cell-associated protein 4, SMAP-4, MFSD1, SMAP4 |
| Target/Specificity | MFSD1; |
| Reconstitution & Storage | MFSD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MFSD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFSD1 (HGNC:25874) |
|---|---|
| Function | Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol (PubMed:38507452). Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (PubMed:30910009). Also essential for liver homeostasis (By similarity). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Note=Also detected in Golgi when overexpressed. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
MFSD1 Antibody: Multidrug transporters, such as MFSD1, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that include uniporters, symporters, and antiporters. Members of this family are found in all living organisms and are highly represented in bacteria. MFS members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFS have provided important insight into the mechanism underlying multidrug transport. MFSD1 is still poorly understood.
REFERENCES
Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
Saidijam M, Benedetti G, Ren Q, et al. Microbial drug efflux proteins of the major facilitator superfamily. Curr. Drug Targets2006; 7:793-811.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
