癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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LRRTM4 Antibody
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Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q86VH4 |
| Other Accession | NP_001128217, 156139147 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 67217 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | LRRTM4 antibody can be used for detection of LRRTM4 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 80059 |
|---|---|
| Other Names | Leucine-rich repeat transmembrane neuronal protein 4, LRRTM4 |
| Target/Specificity | LRRTM4; At least two isoforms of LRRTM4 are known to exist; this antibody will both isoforms. LRRTM4 antibody is predicted to not cross-react with other LRRTM family members. |
| Reconstitution & Storage | LRRTM4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | LRRTM4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRRTM4 |
|---|---|
| Function | May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Postsynaptic cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in neuronal tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
LRRTM4 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Little is known about the function of LRRTM4; in mouse, it is expressed in the limb mesenchyme, neural tube, caudal mesoderm and in three distinct regions of the head. Later expression occurs in a subset of the developing sclerotome. Its similarity to other LRRTM family members suggests that LRRTM4 may also play a role in the development and maintenance of the vertebrate nervous system.
REFERENCES
Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.
Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.
Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.
Haines BP and Rigby PW. Developmentally regualted expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.
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