癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLAMF9 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q96A28 |
| Other Accession | NP_001139645, 226342990 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 32436 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SLAMF9 antibody can be used for detection of SLAMF9 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 89886 |
|---|---|
| Other Names | SLAM family member 9, CD2 family member 10, CD2F-10, CD84 homolog 1, CD84-H1, SLAMF9, CD2F10 |
| Target/Specificity | SLAMF9; SLAMF9 antibody is predicted to not cross-react with other SLAM protein family members. |
| Reconstitution & Storage | SLAMF9 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SLAMF9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLAMF9 |
|---|---|
| Synonyms | CD2F10 |
| Function | May play a role in the immune response. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1 |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLAMF9 Antibody: The SLAM (signalling lymphocyte activation molecule) family is a novel group of receptors on T cells in modulating the immune response. SLAMF9, also known as CD2F-10 or CD84 homolog, is a 289 amino acid type I transmembrane protein that shares 58% identity with the mouse protein. The SLAMF9 protein is predominantly expressed in hematopoietic tissues and contains an extracellular region with only two N-linked glycosylation sites, a 20-residue transmembrane region and a highly positively charged 30-residue cytoplasmic tail, suggesting a role for SLAMF9 as an adhesion molecule. SLAMF9 is thought to function in the immune response as a coreceptor for lymphocyte activation.
REFERENCES
Veillette A and Latour S. The SLAM family of immune-cell receptors. Curr. Opin. Immunol. 2003; 15:277-85.
Veillette A. SLAM family receptors regulate immunity with and without SAP-related adaptors. J. Exp. Med. 2004; 199:1175-8.
Fennelly JA, Tiwari B, Davis SJ, et al. CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily. Immunogenetics 2001; 53:599-602.
Detre C, Keszei M, Romero X, et al. SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin. Immunopathol. 2010; 32:157-71.
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