癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM192 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q8IY95 |
| Other Accession | NP_001093859, 154240704 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 30922 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TMEM192 antibody can be used for detection of TMEM192 by Western blot at 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 201931 |
|---|---|
| Other Names | Transmembrane protein 192, TMEM192 |
| Target/Specificity | TMEM192; At least two isoforms of TMEM192 are known to exist; this antibody will recognize both. TMEM192 antibody is predicted to not cross-react with other TMEM proteins. |
| Reconstitution & Storage | TMEM192 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TMEM192 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM192 |
|---|---|
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Late endosome |
| Tissue Location | Strongly expressed in kidney, liver, lung and pancreas. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMEM192 Antibody: TMEM192 is a widely expressed, four transmembrane protein that localizes to late endosomal/lysosomal membranes. This localization is mediated by two dileucine motifs present at the amino-terminus of TMEM192. A cysteine residue near the carboxy residue is responsible for disulfide bond formation in TMEM192 homodimers. Little is known about the function of this protein.
REFERENCES
Schroder B, Wrocklage C, Hasilik A, et al. Molecular characterisation of ‘transmembrane protein 192'(TMEM192, a novel protein of the lysosomal membrane. Biol. Chem. 2010; 391:695-704.
Zhu H, Liang Z, and Li G. Rabex-5 is a Rab22 effector and mediates a Rab22-Rab5 signaling cascade in endocytosis. Mol. Biol. Cell 2009; 20:4720-9.
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