癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TEKT5 Antibody
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Application 
| WB, E, IHC-P |
|---|---|
| Primary Accession | Q96M29 |
| Other Accession | NP_653275, 21389569 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 56294 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TEKT5 antibody can be used for detection of TEKT5 by Western blot at 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. |
| Gene ID | 146279 |
|---|---|
| Other Names | Tektin-5, TEKT5 |
| Target/Specificity | TEKT5; This antibody is predicted to not cross-react with other Tektin protein family members |
| Reconstitution & Storage | TEKT5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TEKT5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TEKT5 |
|---|---|
| Function | Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme. Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A- tubule of the sperm flagellum. |
| Cellular Location | Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:G5E8A8} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TEKT5 Antibody: Tektins are insoluble alpha-helical proteins related to intermediate filament proteins and are essential for the assembly of cilia and flagella. Tektin-5 (TEKT5) is a recently identified member of the Tektin family. It is predominantly expressed in testis, and its expression is upregulated during testis development. It is present in sperm flagella but not in heads, suggesting that it may act as a middle component required for flagellar stability and sperm mobility.
REFERENCES
Amos LA. The tektin family of microtubule-stabilizing proteins. Genome Biol. 2008; 9:229.
Murayama E, Yamamoto E, Kaneko T, et al. Tektin5, a new Tektin family member, is a component of the middle piece of flagella in rat spermatozoa. Mol. Reprod. Dev. 2008; 75:650-8.
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