癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM204 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q9BSN7 |
| Other Accession | NP_078876, 112807182 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 24540 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TMEM204 antibody can be used for detection of TMEM204 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 79652 |
|---|---|
| Other Names | Transmembrane protein 204, Claudin-like protein 24, TMEM204, C16orf30, CLP24 |
| Target/Specificity | TMEM204; At least two isoforms of TMEM204 are known to exist; this antibody will recognize both isoforms. |
| Reconstitution & Storage | TMEM204 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TMEM204 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM204 |
|---|---|
| Synonyms | C16orf30, CLP24 |
| Function | Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens. |
| Cellular Location | Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with the beta-catenin adherins |
| Tissue Location | Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary Expressed in endothelial and restricted epithelial cell populations |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMEM204 Antibody: Transmembrane protein 204 (TMEM204) is a four-transmembrane protein that is induced under hypoxic conditions. It localizes to cell-cell junctions and co-localizes with the beta-catenin adherens junction-associated protein, but not with tight junctions. Overexpression of TMEM204 results in decreased adhesion between cells, indicating that TMEM204 is an adherens junction protein that modulates cell adhesion and potentially angiogenesis. Recent evidence suggests TMEM204 may also be involved in epilepsy.
REFERENCES
Kearsey J, Petit S, De Oliveira C, et al. A novel four transmembrane spanning protein, CLP24. Eur. J. Biochem. 204; 271:2584-92.
Stefaniuk M and Lukasiuk K. Cloning of expressed sequence tags (ESTs) representing putative epileptogenesis-related genes and the localization of their expression in the normal brain. Neurosci. Lett. 2010; 482:230-4
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