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FXYD7 Antibody
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Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | P58549 |
| Other Accession | AAH18619, 11612659 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 8524 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | FXYD7 antibody can be used for detection of FXYD7 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 53822 |
|---|---|
| Other Names | FXYD domain-containing ion transport regulator 7, FXYD7 |
| Target/Specificity | FXYD7; FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family |
| Reconstitution & Storage | FXYD7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | FXYD7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FXYD7 |
|---|---|
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:33231612). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (PubMed:33231612). Increases the apparent affinity for intracellular Na(+) (PubMed:33231612). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P59648}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P59648} Note=Able to translocate to the plasma membrane independent of its association with NKA (in vitro). {ECO:0000250|UniProtKB:P59649} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.
REFERENCES
Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73
Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Sci. STKE 2003; 2003 (166):RE1.
Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na,K-ATPase. J. Biol. Chem. 2005; 280:42738-43.
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