癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FCHSD1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86WN1 |
| Other Accession | NP_258260, 28875786 |
| Reactivity | Human, Mouse |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Calculated MW | 76942 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | FCHSD1 antibody can be used for detection of FCHSD1 by Western blot at 0.5 - 1 µg/mL. |
| Gene ID | 89848 |
|---|---|
| Other Names | FCH and double SH3 domains protein 1, FCHSD1 |
| Target/Specificity | FCHSD1; Multiple isoforms of FCHSD1 are known to exist. FCHSD1 antibody is predicted to not cross-react with FCHSD2 |
| Reconstitution & Storage | FCHSD1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | FCHSD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FCHSD1 |
|---|---|
| Function | Promotes actin polymerization mediated by SNX9 and WASL. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q6PFY1}. Perikaryon {ECO:0000250|UniProtKB:Q6PFY1}. Cell projection {ECO:0000250|UniProtKB:Q6PFY1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6PFY1}. Note=Detected on neuronal cell bodies and cell projections, in part on cytoplasmic vesicles {ECO:0000250|UniProtKB:Q6PFY1} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FCHSD1 Antibody: The FCH and double SH3 domains protein 1 (FCHSD1, also known as NWK2) and the related protein FCHSD2 were initially identified in silico as distantly related proteins to FNBP1 and FNBP2. Both share the common domain structure consisting of FCH, FBH, two SH3 and C-terminal proline-rich domains. While little is known of the function of FCHSD1, the related protein NWK is an adaptor protein that is thought to regulate Rho activity downstream of Robo receptors, suggesting that FCHSD1 may be involved in synaptic morphology by regulating actin dynamics in presynaptic terminals.
REFERENCES
Kato M and Kato M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int. J. Mol. Med. 2004; 13:749-54.
Coyle IP, Koh YH, Lee WC, et al. Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in drosophila. Neuron 2004; 41:521-34
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