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SLC35D3 Antibody

     
  • 1 - SLC35D3 Antibody ASC11392
    Western blot analysis of SLC35D3 in HeLa cell lysate with SLC35D3 antibody at (A) 1 and (B) 2 µg/mL.
  • 8 - SLC35D3 Antibody ASC11392
    Immunocytochemistry of SLC35D3 in HeLa cells with SLC35D3 antibody at 2.5 µg/mL.
  • 3 - SLC35D3 Antibody ASC11392
    Immunofluorescence of SLC35D3 in HeLa cells with SLC35D3 antibody at 5 µg/mL.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, ICC, E
Primary Accession Q5M8T2
Other Accession AAH87842, 56912198
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 44183 Da
Concentration (mg/ml) 1 mg/mL
Conjugate Unconjugated
Application Notes SLC35D3 antibody can be used for detection of SLC35D3 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 5 µg/mL.
Additional Information
Gene ID 340146
Other Names Solute carrier family 35 member D3, Fringe connection-like protein 1, SLC35D3, FRCL1
Target/Specificity SLC35D3; At least two isoforms of SLC35D3 are known to exist; this antibody will recognize both isoforms. SLC35D3 antibody is predicted to not cross-react with SLC35D1 or SLC35D2.
Reconstitution & Storage SLC35D3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSLC35D3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC35D3 (HGNC:15621)
Function Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (By similarity).
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Early endosome membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGF8}; Multi-pass membrane protein. Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules {ECO:0000250|UniProtKB:Q8BGF8}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

SLC35D3 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The novel protein SLC35D3 is highly homologous to SLC35D1 and SLC35D2, both of which transport UDP-glucuronic acid and UDP-N-acetylgalactosamine, suggesting that SLC35D3 is also involved in the transport of nucleotide sugars. It has been suggested that SLC35D3 regulates platelet dense granules, lysosome-related organelles which contain high concentrations of several biologically important low molecular weight molecules necessary for normal blood homeostasis.

REFERENCES

Ishida N and Kawakita M. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch. 2004; 447:768-75.
Suda T, Kamiyama S, Suzuki M, et al. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. J. Biol. Chem. 2004; 279:26469-74.
Chintala S, Tan J, Gautam R, et al. The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules. Blood 2007; 109:1533-40

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