癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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SPATA19 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z5L4 |
| Other Accession | EAW67810, 28376652 |
| Reactivity | Human, Mouse, Rat |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | IgY |
| Calculated MW | 19186 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SPATA19 antibody can be used for detection of SPATA19 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 219938 |
|---|---|
| Other Names | Spermatogenesis-associated protein 19, mitochondrial, Spermatogenic cell-specific gene 1 protein, Spergen-1, SPATA19, SPERGEN1 |
| Target/Specificity | SPATA19; At least two isoforms of SPATA19 are known to exist; this antibody will detect both isoforms. SPATA19 antibody is predicted to not cross-react with other SPATA family members. |
| Reconstitution & Storage | SPATA19 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SPATA19 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPATA19 |
|---|---|
| Synonyms | SPERGEN1 |
| Function | Essential for sperm motility and male fertility (By similarity). Plays an important role in sperm motility by regulating the organization and function of the mitochondria and is also required for correct sperm midpiece assembly (By similarity). |
| Cellular Location | Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9DAQ9}. Mitochondrion {ECO:0000250|UniProtKB:Q9DAQ9}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAQ9}. Note=Localizes to the midpiece of the sperm flagellum. {ECO:0000250|UniProtKB:Q9DAQ9} |
| Tissue Location | Expressed specifically in testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SPATA19 Antibody: SPATA19, also known as SPERGEN1, was initially identified as a testis-specific protein that localizes to the surface of mitochondria in the middle piece of mature spermatozoa. Recent experiments have shown that elevated levels of SPATA19 have been found in basal cell carcinomas and prostate cancers, suggesting that SPATA19 may serve as a putative cancer biomarker and a target for cancer immunotherapy.
REFERENCES
Miyamoto T, Sengoku K, Hasuike S, et al. Isolation and expression analysis of the human testis-specific gene, SPERGEN-1, a spermatogenic cell-specific gene-1. J. Assist. Reprod. Genet. 2003; 20:101-4.
Doiguchi M, Mori T, Toshimori K, et al. Spergen-1 might be an adhesive molecule associated with mitochondria in the middle piece of spermatozoa. Dev. Biol. 2002; 252:127-37.
Ghafouri-Fard S, Abbasi A, Moslehi H, et al. Elevated levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. Br. J. Dermatol. 2010; 162:772-9
Ghafouri-Fard S, Ousati Ashtiani Z, Sabah Golian B, et al. Expression of two testis-specific genes, SPATA19 and LEMD1, in prostate cancer. Arch. Med. Res. 2010; 41:195-200.
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