癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AIG1 Antibody
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- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q9NVV5 |
| Other Accession | NP_057192, 40316941 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 27458 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | AIG1 antibody can be used for detection of AIG1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL. |
| Gene ID | 51390 |
|---|---|
| Other Names | Androgen-induced gene 1 protein, AIG-1, AIG1 |
| Target/Specificity | AIG1; |
| Reconstitution & Storage | AIG1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | AIG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AIG1 |
|---|---|
| Function | Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
AIG1 Antibody: Androgen-induced 1 (AIG1) is a novel Pirh2-interacting protein, which was initially cloned from human dermal papilla cells and is evolutionally conserved from drosophila through to humans. It is a membrane protein and belongs to the protein family containing FAR-17a domain. AIG1 may play a role in androgen-regulated growth of hair follicles. AIG1 could serve as a new biomarker for the diagnosis and prognostic evaluation of HCCs and may be a novel candidate tumor suppressor.
REFERENCES
Wu G, Sun M, Zhang W, et al. AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway. Front. Biosci. (Elite Ed). 2011; 3:834-42.
Seo J, Kim J, and Kim M. Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells. Mol. Cells 2001; 11:35-40.
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