癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TCTEX1D3 Antibody
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Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8IZS6 |
| Other Accession | NP_777570, 28372535 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 23176 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TCTEX1D3 antibody can be used for detection of TCTEX1D3 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 6991 |
|---|---|
| Other Names | Tctex1 domain-containing protein 3, T-complex testis-specific protein 3, T-complex-associated testis-expressed protein 3, Tcte-3, TCTE3, TCTEX1D3 |
| Target/Specificity | TCTE3; TCTEX1D3 is predicted to not cross-react with other members of the TCTEX-type family |
| Reconstitution & Storage | TCTEX1D3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | TCTEX1D3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DYNLT2 (HGNC:11695) |
|---|---|
| Synonyms | TCTE3, TCTEX1D3 |
| Function | Component of dynein, a family of motor proteins essential for movement along microtubules (PubMed:11278908, PubMed:12584439). Required for structural and functional integrity of cilia (By similarity). Candidate for involvement in male sterility (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P11985}. Cytoplasmic granule {ECO:0000250|UniProtKB:P11985}. Membrane {ECO:0000250|UniProtKB:P11985}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11985}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis {ECO:0000250|UniProtKB:P11985} |
| Tissue Location | Expressed predominantly in testis. Also expressed in brain, lung and trachea. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TCTEX1D3 Antibody: Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D3, also called TCTE3, has been identified as a gene responsible for congenital diaphragmatic hernia (CDH).
REFERENCES
He Y, Francis F, Myers KA, et al. Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. J. Cell Biol. 2005; 168:697-703.
Li J, Lee WL, and Cooper JA. NudEL targets dynein to microtubule ends through LIS1. Nat. Cell Biol. 2005; 7:686-90.
Watanabe TK, Fujiwara T, Shimizu F, et al. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1 to 6q. Cytogenet. Cell Genet. 1996; 73:153-6.
Chuang JZ, Yeh TY, Bollati F, et al. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev. Cell 2005; 9:75-86.
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