癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRIM2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZWJ8 |
| Other Accession | NP_001129386, 209571519 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 166935 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 375616 |
|---|---|
| Other Names | Kielin/chordin-like protein, Cysteine-rich BMP regulator 2, Cysteine-rich motor neuron 2 protein, CRIM-2, Kielin/chordin-like protein 1, KCP-1, KCP, CRIM2, KCP1 |
| Target/Specificity | KCP; At least two isoforms of CRIM2 are known to exist; this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1. |
| Reconstitution & Storage | CRIM2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | CRIM2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KCP (HGNC:17585) |
|---|---|
| Synonyms | CRIM2, KCP1 |
| Function | Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity). |
| Cellular Location | Secreted. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CRIM2 Antibody: CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-β1, suppressing activin- and TGF-β1-dependent transcription.
REFERENCES
Lin J, Patel SR, Cheng X, et al. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat. Med. 2005; 11:387-93
Zeisberg M and Kalluri R. Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. Pediatr. Nephrol. 2008; 23:1395-8.
Lin J, Patel SR, Wang M, et al. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor β/Activin signaling in renal epithelia. Mol. Cell. Biol. 2006; 26:4577-85.
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