癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLAGL2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UPG8 |
| Other Accession | NP_002648, 4505859 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 54584 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | PLAGL2 antibody can be used for detection of PLAGL2 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 5326 |
|---|---|
| Other Names | Zinc finger protein PLAGL2, Pleiomorphic adenoma-like protein 2, PLAGL2, KIAA0198 |
| Target/Specificity | PLAGL2; At least two isoforms are known to exist. |
| Reconstitution & Storage | PLAGL2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | PLAGL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLAGL2 |
|---|---|
| Synonyms | KIAA0198 |
| Function | Shows weak transcriptional activatory activity. |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PLAGL2 Antibody: The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
REFERENCES
Kas K, Voz ML, Hensen K, et al. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J. Biol. Chem. 1998; 273:23026-32.
Voz ML, Agten NS, Van de Ven WJ, et al. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res. 2000; 60:106-13.
Shu G, Tang Y, Zhou Y, et al. Zac1 is a histone acetylation-regulated NF-kappaB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. Cell Death Differ. 2011; 18:1825-35.
Mizutani A, Furukawa T, Adachi Y, et al. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. J. Biol. Chem. 2002; 277:15851-8.
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