癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GHDC Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8N2G8 |
| Other Accession | NP_115873, 14210490 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 57523 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | GHDC antibody can be used for detection of GHDC by Western blot at 0.5 - 1 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 84514 |
|---|---|
| Other Names | GH3 domain-containing protein, GHDC, D11LGP1E, LGP1 |
| Target/Specificity | GHDC; Multiple isoforms are known to exist. |
| Reconstitution & Storage | GHDC antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | GHDC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GHDC |
|---|---|
| Synonyms | D11LGP1E, LGP1 |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99J23}. Nucleus envelope {ECO:0000250|UniProtKB:Q99J23} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GHDC Antibody: GHDC, also known as LGP1, is a GH3 domain-containing protein that is highly expressed in normal mammary tissues and mammary tumors. GHDC is primarily located in the nuclear envelope. In mouse, its gene is located on chromosome 11 adjacent to the STAT3/5 locus. Little is known of the function of this protein.
REFERENCES
Cui Y, Li M, Walton KD, et al. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Genomics 2001; 78:129-34.
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