癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FOXH1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O75593 |
| Other Accession | NP_003914, 4503657 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 39257 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | FOXH1 antibody can be used for detection of FOXH1 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 8928 |
|---|---|
| Other Names | Forkhead box protein H1, Forkhead activin signal transducer 1, Fast-1, hFAST-1, Forkhead activin signal transducer 2, Fast-2, FOXH1, FAST1, FAST2 |
| Target/Specificity | FOXH1; FOXH1 antibody is predicted to not cross-react with any other members of the forkhead box family. |
| Reconstitution & Storage | FOXH1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | FOXH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FOXH1 |
|---|---|
| Synonyms | FAST1, FAST2 |
| Function | Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitous.. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FOXH1 Antibody: FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.
REFERENCES
Chen X, Weisberg E, Fridmacher V, et al. Smad and FAST-1 in the assembly of activin-responsive factor. Nature 1997; 389:85-9.
Zhou S, Zewel L, Lengauer C, et al. Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol. Cell 1998; 2:121-7.
Attisano L, Silvestri C, Izzi L, et al. The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signaling. Mol. Cell. Endocrinol. 2001; 180:3-11.
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