癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GRINA Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z429 |
| Other Accession | NP_001009184, 57165375 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 41203 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 µg/mL. |
| Gene ID | 2907 |
|---|---|
| Other Names | Protein lifeguard 1, Glutamate [NMDA] receptor-associated protein 1, NMDA receptor glutamate-binding subunit, Putative MAPK-activating protein PM02, Transmembrane BAX inhibitor motif-containing protein 3, GRINA, LFG1, NMDARA1, TMBIM3 |
| Target/Specificity | GRINA; GRINA antibody is predicted to not cross-react with other members of the TMBIM family. |
| Reconstitution & Storage | GRINA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | GRINA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRINA |
|---|---|
| Synonyms | LFG1, NMDARA1, TMBIM3 |
| Function | Potential apoptotic regulator. |
| Cellular Location | Membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
REFERENCES
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
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