癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
JAKMIP2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96AA8 |
| Other Accession | NP_055605, 45237195 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 94934 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | JAKMIP2 antibody can be used for detection of JAKMIP2 by Western blot at 1 - 2 µg/mL. |
| Gene ID | 9832 |
|---|---|
| Other Names | Janus kinase and microtubule-interacting protein 2, CTCL tumor antigen HD-CL-04, Neuroendocrine long coiled-coil protein 1, JAKMIP2, JAMIP2, KIAA0555, NECC1 |
| Target/Specificity | JAKMIP2; At least four isoforms of JAKMIP2 are known to exist; this antibody will detect all four isoforms. JAKMIP2 antibody is predicted to not cross-react with JAKMIP1. |
| Reconstitution & Storage | JAKMIP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | JAKMIP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JAKMIP2 |
|---|---|
| Synonyms | JAMIP2, KIAA0555, NECC1 |
| Cellular Location | Golgi apparatus. |
| Tissue Location | Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Also expressed in adrenal and pituitary glands, as well as testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
JAKMIP2 Antibody: JAKMIP2, also known as neuroendocrine long coiled-coil protein 1 (NECC1), is a member of the JAKMIP family of proteins whose members are thought play a role in JAK1 signaling and the regulation of microtubule cytoskeleton rearrangements. JAKMIP2 is expressed predominantly in neuronal cells but unlike JAKMIP1, JAKMIP2 localizes to the Golgi complex. It has been suggested that JAKMIP2 may play important roles in the control of the regulated secretory pathway.
REFERENCES
Steindler C, Li Z, Algarte M, et al. Jamip1 (Marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. J. Biol. Chem. 2004; 279:43168-77.
Cruz-Garcia D, Vazquez-Martinez R, Peinado JR, et al. Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. FEBS Lett. 2007; 581:3149-56.
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