癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMEM135 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q86UB9 |
| Other Accession | NP_075069, 281182571 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 52291 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TMEM135 Antibody can be used for detection of TMEM135 by Western blot starting at 1 µg/mL. |
| Gene ID | 65084 |
|---|---|
| Other Names | Transmembrane protein 135, Peroxisomal membrane protein 52, PMP52, TMEM135 |
| Target/Specificity | TMEM135; At least two isoforms of TMEM135 are known to exist; this antibody will detect both isoforms. |
| Reconstitution & Storage | TMEM135 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | TMEM135 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMEM135 (HGNC:26167) |
|---|---|
| Function | Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization. |
| Cellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMEM135 Antibody: The transmembrane protein 135 (TMEM135), also known as peroxisomal membrane protein 52 (PMP52), was initially identified as a protein that might be critical for adipogenesis and osteoblastogenesis. Further studies have indicated that TMEM135 may be part of a regulatory circuit that plays an important role in fat metabolism and energy expenditure in both C. elegans as well as mammalian organisms. Finally, recent experiments has suggested that TMEM135 may be an additional driver of breast cancer.
REFERENCES
Scheideler M, Elabd C, Zaragosi LE, et al. Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis. BMC Genomics 2008; 9:340.
Exil VJ, Avila DS, Benedetto A, et al. Stress-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longetivity regulation in Caenorhabditis elegans. PLoS One 2010; 5:e14228.
Natrajan R, Mackay A, Lambros MB, et al. A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and –positive breast cancers. J. Pathol. 2012; 227:29-41.
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