癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC27A6 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9Y2P4 |
| Other Accession | NP_054750, 13325055 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 70112 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SLC27A6 antibody can be used for detection of SLC27A6 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 28965 |
|---|---|
| Other Names | Long-chain fatty acid transport protein 6, FATP-6, Fatty acid transport protein 6, Fatty-acid-coenzyme A ligase, very long-chain 2, Solute carrier family 27 member 6, Very long-chain acyl-CoA synthetase homolog 1, VLCSH1, hVLCS-H1, SLC27A6, ACSVL2, FACVL2, FATP1 |
| Target/Specificity | SLC27A6; SLC27A6 antibody is predicted to not cross-react with other SLC27 protein family members. |
| Reconstitution & Storage | SLC27A6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SLC27A6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC27A6 |
|---|---|
| Synonyms | ACSVL2, FACVL2, FATP6 |
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long- chain fatty acids (VLCFA) as substrates (By similarity). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation such as the heart (PubMed:12556534). |
| Cellular Location | Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:E9Q9W4}; Multi-pass membrane protein. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. |
| Tissue Location | Strongly expressed in heart and localizes to cardiac myocytes (PubMed:12556534). Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC27A6 Antibody: The solute carrier family 27 (fatty acid transporter), member 6 (SLC27A6) is a member of the fatty acid transport protein family (FATP), which are involved in the uptake of long-chain fatty acids. SLC27A6 is principally expressed in the heart on the sarcolemma and colocalizes with CD36, another molecule involved in the uptake of long chain fatty acids.
REFERENCES
Gimeno RE, Ortegon AM, Patel S, et al. Characterization of a heart-specific fatty acid transport protein. J. Biol. Chem. 2003;278:16039-44.
Fisher RM and Gertow K. Fatty acid transport proteins and insulin resistance. Curr. Opin. Lipidol. 2005; 16:173-8.
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