癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KANK3 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E, IHC-P |
|---|---|
| Primary Accession | Q6NY19 |
| Other Accession | NP_940873, 157504499 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 85893 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | KANK3 Antibody can be used for detection of KANK3 by Western blot starting at 1 µg/mL. |
| Gene ID | 256949 |
|---|---|
| Other Names | KN motif and ankyrin repeat domain-containing protein 3, Ankyrin repeat domain-containing protein 47, KANK3, ANKRD47 |
| Target/Specificity | KANK3; Two alternatively spliced transcript variants encoding different isoforms have been identified. |
| Reconstitution & Storage | KANK3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | KANK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KANK3 (HGNC:24796) |
|---|---|
| Synonyms | ANKRD47 |
| Function | May be involved in the control of cytoskeleton formation by regulating actin polymerization. |
| Tissue Location | Strongly expressed in breast, liver, lung, skeletal muscle and kidney. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KANK3 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. Like other members of the KANK family, KANK3 (KN motif and ankyrin repeat domain-containing protein 3), is thought to play a role in the formation of actin stress fibers. In zebrafish, the homolog of KANK3 interacts with the adaptor protein Numb, a protein implicated in multiple basic cellular processes, and is essential for epidermal integrity and neurulation, suggesting that KANK3 may play a similar role in higher organisms.
REFERENCES
Zhu Y, Kakinuma N, Wang Y, et al. Kank proteins: a new family of ankyrin-repeat domain containing proteins. Biochim. Biophys. Acta 2008; 1780:128-33.
Roy BC, Kakinuma N, Kiyama R. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J. Cell Biol. 2009; 184:253-67.
Boggetti B, Jasik J, Takamiya M, et al. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Dev. Biol. 2012; 365:164-74.
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