癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Heartland Virus Glycoprotein 1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | J3WAX0 |
| Other Accession | AFP33393, 399207766 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 116766 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | Heartland virus glycoprotein 1 antibody can detect 10 ng Heartland virus glycoprotein 1 in ELISA at 1 µg/mL. |
| Gene ID | 19893498 |
|---|---|
| Reconstitution & Storage | Heartland virus glycoprotein 1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | Heartland Virus Glycoprotein 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GP |
|---|---|
| Function | [Glycoprotein N]: Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion (Probable). Plays a role in the packaging of ribonucleoproteins during virus assembly (By similarity). |
| Cellular Location | [Glycoprotein N]: Virion membrane {ECO:0000250|UniProtKB:P09613}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P09613}. Host Golgi apparatus membrane {ECO:0000250|UniProtKB:P03518}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P09613}. Host endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09613}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P09613}. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs {ECO:0000250|UniProtKB:P09613} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Heartland Virus Glycoprotein 1 Antibody: The Heartland virus is a newly identified member of the phlebovirus genus of the Bunyaviridae family. Initial reports indicate that symptoms may include fever, fatigue, diarrhea, thrombocytopenia, and leukopenia (1). The Bunyaviridae family of viruses are spherical enveloped viruses with a tripartite RNA genome of negative or ambisense polarity (2). The glycoprotein RNA encodes a polyprotein that is cleaved into the G1 and G2 proteins.
REFERENCES
McMullan LK, Folk SM, Kelly AJ, et al. A new phlebovirus associated with severe febrile illness in Missouri. N. Engl. J. Med. 2012; 367:834-41.
Schmaljohn C and Hooper JW. Bunyaviridae: the viruses and their replication, 4th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
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