癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WFDC2 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q14508 |
| Other Accession | NP_006094, 56699495 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 12993 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | WFDC2 antibody can be used for detection of WFDC2 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 10406 |
|---|---|
| Other Names | WAP four-disulfide core domain protein 2, Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2, HE4, WAP5 |
| Target/Specificity | WFDC2; WFDC2 antibody is human specific. Multiple isoforms of WFDC2 are known to exist. |
| Reconstitution & Storage | WFDC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | WFDC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WFDC2 (HGNC:15939) |
|---|---|
| Function | Plays a critical role in lung development (By similarity). Required for terminal differentiation of bronchiole club cells (By similarity). Required for development of airway barrier mechanisms, such as lamellar body formation in type II alveolar epithelial cells and cilia formation on ciliated epithelial cells following initiation of respiration at birth (By similarity). Required for type I alveolar epithelial cell and vascular endothelial development in the lungs, thereby mediating blood-air barrier exchange (By similarity). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in lung, trachea, kidney, breast, fallopian tubes, endometrium, cervix, epididymis and prostate |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The WAP four-disulfide core domain protein 2 (WFDC2), also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1,2). Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system (2). WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer (3).
REFERENCES
Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serious and endometrioid ovarian carcinomas. Cancer Res. 2005; 65:2162-9.
Bingle L, Cross SS, High AS, et al. WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Resp. Res. 2006; 7:61.
Chen Y, Mu X, Wang S, et al. WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol. Rep. 2013; 29:288-96.
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