癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL-28B Antibody
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- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q8IZI9 |
| Other Accession | NP_742151, 28144901 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 21706 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | IL-28B antibody can be used for detection of IL-28B by Western blot at 1 - 2 µg/ml. |
| Gene ID | 282617 |
|---|---|
| Other Names | Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22 |
| Target/Specificity | IFNL3; IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29. |
| Reconstitution & Storage | IL-28B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | IL-28B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFNL3 |
|---|---|
| Synonyms | IL28B, IL28C, ZCYTO22 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Cellular Location | Secreted. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1). The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3). All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1).
REFERENCES
Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 2003; 4:63-8.
Osterlund PI, Pietila TE, Veckman V, et al. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J. Immunol. 2007; 179:3434-42.
Meager A, Visvalingam K, Dilger P, et al. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine 2005; 31:109-18.
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