癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IL28B antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8IZI9 |
| Other Accession | NM_172139, NP_742151 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Horse |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21706 Da |
| Gene ID | 282617 |
|---|---|
| Alias Symbol | IFNL3, IL-28B, IL28C, IL28B |
| Other Names | Interferon lambda-3, IFN-lambda-3, Cytokine Zcyto22, Interleukin-28B, IL-28B, Interleukin-28C, IL-28C, IFNL3, IL28B, IL28C, ZCYTO22 |
| Target/Specificity | This antibody is pan-IL28 specific, as there is 100% homology to the human IL28A sequence, per http://www.uniprot.org/uniprot/Q8IZJ0. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-IL28B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | IL28B antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFNL3 |
|---|---|
| Synonyms | IL28B, IL28C, ZCYTO22 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)- induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. |
| Cellular Location | Secreted. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Sheppard P.,et al.Nat. Immunol. 4:63-68(2003).
Kotenko S.V.,et al.Nat. Immunol. 4:69-77(2003).
Li M.C.,et al.Acta Pharmacol. Sin. 27:453-459(2006).
Grimwood J.,et al.Nature 428:529-535(2004).
Donnelly R.P.,et al.J. Interferon Cytokine Res. 30:555-564(2010).
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