癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RPSA Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | P08865 |
| Other Accession | NP_002286, 9845502 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 32854 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | RPSA antibody can be used for detection of RPSA by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 3921 |
|---|---|
| Other Names | 40S ribosomal protein SA {ECO:0000255|HAMAP-Rule:MF_03016}, 37 kDa laminin receptor precursor {ECO:0000255|HAMAP-Rule:MF_03016}, 37LRP {ECO:0000255|HAMAP-Rule:MF_03016}, 37/67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}, LRP/LR {ECO:0000255|HAMAP-Rule:MF_03016}, 67 kDa laminin receptor {ECO:0000255|HAMAP-Rule:MF_03016}, 67LR {ECO:0000255|HAMAP-Rule:MF_03016}, Colon carcinoma laminin-binding protein, Laminin receptor 1 {ECO:0000255|HAMAP-Rule:MF_03016}, LamR {ECO:0000255|HAMAP-Rule:MF_03016}, Laminin-binding protein precursor p40 {ECO:0000255|HAMAP-Rule:MF_03016}, LBP/p40 {ECO:0000255|HAMAP-Rule:MF_03016}, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, RPSA {ECO:0000255|HAMAP-Rule:MF_03016}, LAMBR, LAMR1 |
| Target/Specificity | RPSA; RPSA antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | RPSA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | RPSA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RPSA {ECO:0000255|HAMAP-Rule:MF_03016} |
|---|---|
| Synonyms | LAMBR, LAMR1 |
| Function | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. |
| Cellular Location | Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity) Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP- Rule:MF_03016} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1). Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2). RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3).
REFERENCES
Jackers P, Minoletti F, Belotti D, et al. Isolation from a multigene family of the active human gene of the metastasis-associated 67kDa laminin binding protein 37LRP/p40 at chromosome 3p21.3. Oncogene 1996; 13:495-503.
Savino W and Silva-Barbosa SD. Laminin/VLA-6 interactions and T cell function. Braz. J. Med. Biol. Res. 1996; 29:1209-20.
Kumazoe M, Sugihara K, Tsukamoto S, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest. 2013; 123:787-99.
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