癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Puumala Virus Glycoprotein Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P27312 |
| Other Accession | AFQ60650, 402502305 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 126294 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | Puumala virus glycoprotein antibody can detect 10ng Puumala virus glycoprotein peptide in ELISA at 1 µg/ml. |
| Gene ID | 2943082 |
|---|---|
| Other Names | Envelope glycoprotein, GP, M polyprotein, Glycoprotein G1, Glycoprotein G2, GP |
| Target/Specificity | PUUVsMgp1; |
| Reconstitution & Storage | Puumala virus glycoprotein antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | Puumala Virus Glycoprotein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GP |
|---|---|
| Function | [Glycoprotein N]: Forms homotetramers with glycoprotein C at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (PubMed:24755564). May dysregulate normal immune and endothelial cell responses through an ITAM motif (By similarity). Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (By similarity). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (By similarity). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (By similarity). Interacts with the viral genomic RNA (PubMed:21807393). |
| Cellular Location | [Glycoprotein N]: Virion membrane {ECO:0000250|UniProtKB:P08668}; Multi-pass membrane protein. Host cell surface. Host Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08668}. Host endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08668}. Host mitochondrion {ECO:0000250|UniProtKB:P08668}. Note=Interaction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Puumala virus (PUUV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) and is highly homologous to the protype hantavirus Hantaan virus (1). Like other hantaviruses, the PUUV glycoprotein is synthesized as a precursor that is posttranslationally processed into two glycoproteins G1 (Gn) and G2 (Gc). These glycoproteins interact with the PUUV nucleocapsid (NP) protein through their cytoplasmic tail, and this association has been suggested to be crucial to the binding of the ribonucleoprotein of the PUUV and the assembly of the virus particle (2).
REFERENCES
Vapalahti O, Kallio-Kokko H, Salonen EM, et al. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J. Gen. Virol. 1992; 73:829-38.
Hepojoki J, Strandin T, Wang H, et al. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 2010; 91:2341-50.
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