癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Puumala Virus Nucleocapsid Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | P27313 |
| Other Accession | ABO93592, 144228123 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 49452 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | Puumala virus nucleocapsid antibody can detect 10ng Puumala virus nucleocapsid peptide in ELISA at 1 µg/ml. |
| Gene ID | 2943083 |
|---|---|
| Other Names | Nucleoprotein, Nucleocapsid protein, Protein N, N |
| Target/Specificity | PUUVsSgp1; |
| Reconstitution & Storage | Puumala virus nucleocapsid antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | Puumala Virus Nucleocapsid Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | N |
|---|---|
| Function | Encapsidates the genome protecting it from nucleases (Probable). The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable). The nucleocapsid has a left-handed helical structure (By similarity). As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (By similarity). Involved in the transcription and replication initiation of vRNA by mediating primer annealing (By similarity). Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (By similarity). Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (By similarity). Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (By similarity). Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (By similarity). Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity). Also displays sequence-unspecific DNA endonuclease activity (By similarity). |
| Cellular Location | Virion {ECO:0000250|UniProtKB:P05133}. Host cytoplasm, host perinuclear region. Host Golgi apparatus, host cis-Golgi network {ECO:0000250|UniProtKB:P05133} Note=Internal protein of virus particle {ECO:0000250|UniProtKB:P05133} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Puumala virus (PUUV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) and is highly homologous to the protype hantavirus Hantaan virus (1). Like other hantaviruses, the PUUV glycoprotein is synthesized as a precursor that is posttranslationally processed into two glycoproteins G1 (Gn) and G2 (Gc). These glycoproteins interact with the PUUV nucleocapsid (NP) protein through their cytoplasmic tail, and this association has been suggested to be crucial to the binding of the ribonucleoprotein of the PUUV and the assembly of the virus particle (2).
REFERENCES
Vapalahti O, Kallio-Kokko H, Salonen EM, et al. Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein. J. Gen. Virol. 1992; 73:829-38.
Hepojoki J, Strandin T, Wang H, et al. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 2010; 91:2341-50.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
