癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TOPAZ1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E, IHC-P |
|---|---|
| Primary Accession | Q8N9V7 |
| Other Accession | NP_001138502, 222537754 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 190927 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | TOPAZ1 antibody can be used for detection of TOPAZ1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL. |
| Gene ID | 375337 |
|---|---|
| Other Names | Testis- and ovary-specific PAZ domain-containing protein 1, TOPAZ1, C3orf77 |
| Target/Specificity | TOPAZ1; TOPAZ1 antibody is human, mouse and rat reactive. At least three isoforms of TOPAZ1 are known to exist. |
| Reconstitution & Storage | TOPAZ1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | TOPAZ1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TOPAZ1 |
|---|---|
| Synonyms | C3orf77 |
| Function | Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:E5FYH1} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The testis and ovary specific PAZ domain containing 1 (TOPAZ1) protein is a highly conserved protein that is highly expressed in the gonads during germ cell meiosis, suggesting that it may play a role in germ cell development (1). It contains a PAZ domain and a zinc finger domain and is exclusively expressed in adult testis and fetal ovary.
REFERENCES
Baillet A, Le Bouffant R, Volff JN, et al. TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates. PLoS One 2011; 6:e26950.
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