癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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OASL Antibody
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- 实验流程
- 背景知识
Application 
| WB, IF, ICC, E |
|---|---|
| Primary Accession | Q15646 |
| Other Accession | NP_003724, 11321577 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 59226 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | OASL antibody can be used for detection of OASL by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunocytochemistry at 2.5 µg/mL. For Immunoflorescence start at 20 µg/mL. |
| Gene ID | 8638 |
|---|---|
| Other Names | 2'-5'-oligoadenylate synthase-like protein, 2'-5'-OAS-related protein, 2'-5'-OAS-RP, 59 kDa 2'-5'-oligoadenylate synthase-like protein, Thyroid receptor-interacting protein 14, TR-interacting protein 14, TRIP-14, p59 OASL, p59OASL, OASL, TRIP14 |
| Target/Specificity | OASL; OASL antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | OASL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | OASL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OASL |
|---|---|
| Synonyms | TRIP14 |
| Function | Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. |
| Cellular Location | [Isoform p56]: Nucleus, nucleolus. Cytoplasm. |
| Tissue Location | Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).
REFERENCES
Rebouillat D, Marie I, and Hovanessian AG. Molecular cloning and characterization of two related and interferon-induced 56 kDa and 30 kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Eur. J. Biochem. 1998; 257:319-30.
Hartmann R, Olsen HS, Widder S, et al. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res. 1998; 26:4121-8.
Hovnanian A, Rebouillat D, Levy ER, et al. The human 2',5'-oligoadenylate synthetaselike gene (OASL) encoding the interferon-induced 56 kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Genomics 1999; 56:362-3.
Andersen JB, Strandbygård DJ, Hartmann R, et al. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Eur. J. Biochem. 2004; 271:628-36.
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