癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOX17 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q9H6I2 |
| Other Accession | NP_071899, 11967991 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 44117 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SOX17 antibody can be used for detection of SOX17 by Western blot at 0.5 - 1 µg/ml. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 64321 |
|---|---|
| Other Names | Transcription factor SOX-17, SOX17 |
| Target/Specificity | SOX17; SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins. |
| Reconstitution & Storage | SOX17 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SOX17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX17 |
|---|---|
| Function | Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'- AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. |
| Tissue Location | Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2). SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4). SOX17 is also essential for acquisition and maintenance of arterial identity (5).
REFERENCES
Kanai Y, Kanai-Azuma M, Noce T, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 1996; 133:667-81.
Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.
Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.
Kim I, Saunders TL, and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130:470-83.
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