癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SOX18 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P35713 |
| Other Accession | NP_060889, 8924248 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 40891 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | SOX18 antibody can be used for detection of SOX18 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 54345 |
|---|---|
| Other Names | Transcription factor SOX-18, SOX18 |
| Target/Specificity | SOX18; SOX18 antibody is human, mouse and rat reactive. SOX18 is predicted to not cross-react with other SOX proteins. |
| Reconstitution & Storage | SOX18 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | SOX18 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX18 |
|---|---|
| Function | Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction with MEF2C enhances transcriptional activation. Besides, required for normal hair development. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. |
| Tissue Location | Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2). SOX18 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types (3). SOX is known to be involved with vascularization and endothelial development, suggesting that it may be useful as a potential target for inhibiting tumor angiogenesis (4). Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia (5).
REFERENCES
Dunn TL, Mynett-Johnson L, Wright EM, et al. Sequence and expression of Sox-18 encoding another HMG-box transcription factor. Gene 1995; 161:223-5.
Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.
Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.
Young N, Hahn CN, Poh A, et al. Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J. Natl. Cancer Inst. 2006; 98:1060-7.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
