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NOX1 Antibody

     
  • 1 - NOX1 Antibody ASC11832
    Western blot analysis of NOX1 in 293 cell lysate with NOX1 antibody at 1 µg/ml.
  • 2 - NOX1 Antibody ASC11832
    Immunohistochemistry of NOX1 in human kidney tissue with NOX1 antibody at 5 µg/ml.
  • 3 - NOX1 Antibody ASC11832
    Immunofluorescence of NOX1 in human kidney tissue with NOX1 antibody at 20 µg/ml.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, E, IHC-P
Primary Accession Q9Y5S8
Other Accession NP_008983, 148536873
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 64871 Da
Concentration (mg/ml) 1 mg/mL
Conjugate Unconjugated
Application Notes NOX1 antibody can be used for detection of NOX1 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 27035
Other Names NADPH oxidase 1, NOX-1, 1.-.-.-, Mitogenic oxidase 1, MOX-1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NOH-1, NOX1, MOX1, NOH1
Target/Specificity NOX1; NOX1 antibody is human specific.
Reconstitution & Storage NOX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsNOX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NOX1 (HGNC:7889)
Synonyms MOX1, NOH1
Function NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.
Cellular Location Cell projection, invadopodium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location [Isoform NOH-1L]: Detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress (1). NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox (1). Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv (2). NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain (1-3). NOX1 have the potential to be effective treatments for a range of ischemic diseases (4).

REFERENCES

Helmcke I, Heumuller S, Tikkanen R, et al. Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid. Redox Signal. 2009; 11:1279-87.
Piccoli C, D'Aprile A, Ripoli M, et al. Bone-marrow derived hematopoietic stem/progenitor cells express multiple isoforms of NADPH oxidase and produce constitutively reactive oxygen species. Biochem. Biophys. Res. Commun. 2007; 353:965-72.
Lee JG, Lim EJ, Park DW, et al. A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation. Cell Signal. 2008; 20:2266-75.
Stanic B, Katsuyama M, and Miller FJ Jr. An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. Arterioscler. Thromb. Vasc. Biol. 2010; 30:2234-41.

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