癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GJB2 Antibody
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P29033 |
| Other Accession | NP_003995, 42558283 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 26215 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | GJB2 antibody can be used for detection of GJB2 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 2706 |
|---|---|
| Other Names | Gap junction beta-2 protein, Connexin-26, Cx26, GJB2 |
| Target/Specificity | GJB2; GJB2 antibody is human specific. |
| Reconstitution & Storage | GJB2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | GJB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GJB2 |
|---|---|
| Function | Structural component of gap junctions (PubMed:16849369, PubMed:17551008, PubMed:19340074, PubMed:19384972, PubMed:21094651, PubMed:26753910). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (PubMed:17551008, PubMed:19340074, PubMed:21094651, PubMed:26753910). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:16849369, PubMed:19384972, PubMed:21094651). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Note=Colocalizes with GJB4 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q00977} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Gap junction beta-2 protein (GJB2), also known as Connexin 26, is member of the gap junction protein family which form structures that were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells (1). Mutations in the GJB2 gene are thought to be responsible for as much as 35-45% of congenital sensorineural hearing loss in some populations (2). Other mutations in this gene have also been linked to a wide array of skin diseases (3).
REFERENCES
Zhou JZ and Jiang JX. Gap junctions and hemichannel-independent actions of connexins on cell and tissue functions – An update. FEBS Lett. 2014; 588:1186-92.
Petit C, Levilliers J, and Hardelin JP. Molecular genetics of hearing loss. Annu. Rev. Genet. 2001; 35:589-646.
Gerido DA and White TW. Connexin disorders of the ear, skin, and lens. Biochim. Biophys. Acta. 2004; 1662:159-70.
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