癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRRX1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P54821 |
| Other Accession | NP_073207, 12707577 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 27296 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | PRRX1 antibody can be used for detection of PRRX1 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 5396 |
|---|---|
| Other Names | Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1, PRRX1, PMX1 |
| Target/Specificity | PRRX1; PRRX1 antibody is human, mouse and rat reactive. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms. |
| Reconstitution & Storage | PRRX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | PRRX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRRX1 |
|---|---|
| Synonyms | PMX1 |
| Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P63013}. |
| Tissue Location | [Isoform 1]: Widely expressed in embryonic and adult tissues, with highest levels in skeletal muscle. Isoform 1 is either expressed at similar or higher levels compared to isoform 2 in all embryonic tissues but skeletal muscle and heart. In adult tissues, expressed at lower levels compared to isoform 2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The paired related homeobox protein 1 (PRRX1) is a paired-type DNA-binding homeodomain that plays an important role as a key switch for neural cell lineage determination and is essential for development (1,2). PRRX1 is expressed in a number of undifferentiated mesenchymal cells in mouse embryos and adults (3). Mice with a disrupted PRRX1 gene show perinatal death with craniofacial and limb malformations (4). Low PRRX1 expression levels were significantly associated with metastasis and poor prognosis of breast and colorectal cancer (5).
REFERENCES
Nohno T, Koyama E, Myokai F, et al. Chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb. Dev. Biol. 1993; 158:254–64.
Shimozaki K, Clemenson GD Jr, and Gage FH. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J. Neurosci. 2013; 33:4066-75.
Cserjesi P, Lilly B, Bryson L, et al. MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer. Development 1992; 115:1087–101.
Lu MF, Cheng HT, Kern MJ, et al. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 1999; 126:495–504.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
