癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AJAP1 Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UKB5 |
| Other Accession | NP_061324, 9055278 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 44536 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | AJAP1 antibody can be used for detection of AJAP1 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 55966 |
|---|---|
| Other Names | Adherens junction-associated protein 1, Membrane protein shrew-1, AJAP1, MOT8, SHREW1 |
| Target/Specificity | AJAP1; AJAP1 antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | AJAP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | AJAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AJAP1 |
|---|---|
| Synonyms | MOT8, SHREW1 |
| Function | Plays a role in cell adhesion and cell migration. |
| Cellular Location | Basolateral cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Mainly basolateral (PubMed:16707570). Localization is mediated by AP1M2 (PubMed:16707570). |
| Tissue Location | Expressed in uterus and pancreas (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration (1). It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium (1,2). AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation (3). This facilitates the dissolution of adherens junctions with an increase in cell motility (3,4).
REFERENCES
Zeng L, Fee BE, Rivas MV, et al. Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review). Int. J. Oncol. 2014; 45:13-7.
Han L, Zhang KL, Zhang JX, et al. AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci. Ther. 2014; 20:429-37.
Gross JC, Schreiner A, Engels K, et al. E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1. Mol. Biol. Cell 2009; 20:3598-607.
Lin N, Di C, Bortoff K, et al. Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol. Cancer Res. 2012; 10:208-17.
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