癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GAS6 Antibody
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- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q14393 |
| Other Accession | NP_000811, 4557617 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 74925 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | GAS6 antibody can be used for the detection of GAS6 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. |
| Gene ID | 2621 |
|---|---|
| Other Names | Growth arrest-specific protein 6, GAS-6, AXL receptor tyrosine kinase ligand, GAS6, AXLLG |
| Target/Specificity | GAS6; GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform. |
| Reconstitution & Storage | GAS6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | GAS6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAS6 (HGNC:4168) |
|---|---|
| Synonyms | AXLLG |
| Function | Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. |
| Cellular Location | Secreted. |
| Tissue Location | Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla)-containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2). GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3). This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4). Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2).
REFERENCES
Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93.
Laurance S, Lemarie CA, and Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv. Nutr. 2012; 3:196-203.
Stitt TN, Conn G, Gore M, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80:661-70.
van der Meer JH, van der Poll T, and van ‘t Veer C. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. Blood 2014; 123:2460-9.
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