癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CHADL Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6NUI6 |
| Other Accession | NP_612490, 194440719 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 82388 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | CHADL antibody can be used for the detection of CHADL by Western blot at 1 - 2 µg/mL. |
| Gene ID | 150356 |
|---|---|
| Other Names | Chondroadherin-like protein, CHADL, SLRR4B |
| Target/Specificity | CHADL; CHADL antibody is human, mouse and rat reactive. CHADL antibody is predicted to not cross-react with Chondroadherin protein. |
| Reconstitution & Storage | CHADL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | CHADL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHADL |
|---|---|
| Synonyms | SLRR4B |
| Function | Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:E9Q7T7} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Chondroadherin-like (CHADL) protein, also known as SLRR4B, is homologous to the Chondroadherin protein and is expressed cartillaginous tissues (1). Like Chondroadherin, CHADL belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily and plays a significant role in the regulation of chondrocyte growth and proliferation (1,2). CHADL is thought to play a negative regualtory role in collagen fibrillogenesis and chondrocyte differentiation (1).
REFERENCES
Tillgren V, Ho JC, Onnerfjord P, et al. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentitation. J. Biol. Chem. 2015; 290:918-25.
Neame PJ, Sommarin Y, Boynton RE, et al. The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. J. Biol. Chem. 1994; 269:21547-54.
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