癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SARS-CoV-2 (COVID-19) NSP12 Antibody
Infectious Disease, COVID-19
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P0DTC1 |
| Other Accession | 7B3D_A |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | RdRp |
| Calculated MW | 489989 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | WB: 1-2 μg/mL Antibody validated: SARS-CoV-2 (COVID-19) NSP12 antibody can detect 2 ng of free peptide at 1 µg/mL in ELISA. It can detect SARS-CoV-2 NSP12 recombinant protein by ELISA and WB. All other applications and species not yet tested. |
| Gene ID | 43740578 |
|---|---|
| Other Names | RNA-directed RNA polymerase, Pol, RdRp, NSP12, Non-structure protein 12 |
| Reconstitution & Storage | SARS-CoV-2 (COVID-19) NSP12 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | SARS-CoV-2 (COVID-19) NSP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | R1A |
|---|---|
| Function | [Replicase polyprotein 1a]: Multifunctional protein involved in the transcription and replication of viral RNAs. Contains the proteinases responsible for the cleavages of the polyprotein. |
| Cellular Location | [Host translation inhibitor nsp1]: Host cytoplasm [Papain-like protease nsp3]: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes in virally-induced cytoplasmic double-membrane vesicles (DMV) [3C-like proteinase nsp5]: Host cytoplasm. Host Golgi apparatus. Host nucleus [Non-structural protein 7]: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P0C6X9}. Host cytoplasm. Host endoplasmic reticulum. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes. {ECO:0000250|UniProtKB:P0C6X9} [RNA-capping enzyme subunit nsp9]: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:P0C6X9}. Host cytoplasm Host endoplasmic reticulum. Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes {ECO:0000250|UniProtKB:P0C6X9} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. NSP12 interacts with nsp7 and nsp8.
REFERENCES
Gorbalenya. bioRxiv: 2020.;Hui et al. Int J Infect Dis. 2020;91:264-266.;;;;;;;;;
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