癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LpxT Antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | P76445 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Clone Names | lpxT |
| Calculated MW | 26759 Da |
| Concentration (mg/ml) | 1 mg/mL |
| Conjugate | Unconjugated |
| Application Notes | WB: 0.5 μg/mL. Antibody validated: Western Blot in E.coli samples. All other applications and species not yet tested. |
| Gene ID | 75172303;946693 |
|---|---|
| Alias Symbol | lpxT |
| Other Names | Lipid A 1-diphosphate synthase, Kdo(2)-lipid A phosphotransferase, Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase, Eck2168, yeiU |
| Reconstitution & Storage | LpxT Antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | LpxT Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | lpxT {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000303|PubMed:18047581} |
|---|---|
| Function | Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P) (PubMed:18047581). In vitro, has low undecaprenyl-diphosphate phosphatase activity (PubMed:17660416). |
| Cellular Location | Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01945, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:17660416}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:17660416} Note=Transferase activity takes place on the periplamic side of the inner membrane. {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
LpxT is involved in the modification of the lipid A domain of lipopolysaccharides (LPS) and transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate as well as contributes to the recycling of undecaprenyl phosphate (C55-P). In vitro, it has low undecaprenyl-diphosphate phosphatase activity.
REFERENCES
Touze, et al. Mol Microbiol. 2008; 67(2): 267-77.Tatar, et al. Microbiology 2007; 153(Pt8): 2518-2529.
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