Nipah virus/NiV M/Matrix Recombinant protein

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, E, IM
Primary Accession	Q9IK90
Calculated MW	39928 Da

Additional Information
Gene ID	920953
Other Names	Matrix protein, Protein M, M protein, Nipah Virus (NiV)
Reconstitution & Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for one week. Store at -20 to -80 ˚C for twelve months from the date of receipt.
Precautions	Nipah virus/NiV M/Matrix Recombinant protein is for research use only and not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	M
Function	Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane (PubMed:17005661, PubMed:17204159, PubMed:19000317). Transits through the host nucleus before gaining the functional ability to localize and bud from the plasma membrane (PubMed:21085610). Mediates together with fusion protein the incorporation of the glycoprotein to the viral particles (PubMed:28250132). Also participates in the inhibition of the host interferon type I antiviral response by interacting with and thereby inhibiting host TRIM6 (PubMed:27622505).
Cellular Location	Virion. Host cytoplasm. Host cell membrane. Host nucleus. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells. Nuclear- cytoplasmic trafficking is essential for budding and requires matrix ubiquitination.