癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AAAS Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant AAAS.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9NRG9 |
| Other Accession | NM_015665 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5A1 |
| Calculated MW | 59574 Da |
| Gene ID | 8086 |
|---|---|
| Other Names | Aladin, Adracalin, AAAS, ADRACALA |
| Target/Specificity | AAAS (NP_056480, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | AAAS Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Two Italian patients with novel AAAS gene mutation expand allelic and phenotypic spectrum of triple A (Allgrove) syndrome. Palka C, et al. Clin Genet, 2010 Mar. PMID 20447142.Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism. Storr HL, et al. Mol Endocrinol, 2009 Dec. PMID 19855093.The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope. Kind B, et al. Biochem Biophys Res Commun, 2009 Dec 11. PMID 19782045.The transmembrane nucleoporin NDC1 is required for targeting of ALADIN to nuclear pore complexes. Yamazumi Y, et al. Biochem Biophys Res Commun, 2009 Nov 6. PMID 19703420.Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome. Cho AR, et al. Exp Mol Med, 2009 Jun 30. PMID 19322026.
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