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>   首页   >   产品   >   一抗   >   代谢   >   ABCC6 Antibody (monoclonal) (M02)   

ABCC6 Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant ABCC6.

     
  • 1 - ABCC6 Antibody (monoclonal) (M02) AT1008a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • 10 - ABCC6 Antibody (monoclonal) (M02) AT1008a
    Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession O95255
Other Accession NM_001171
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG1 Kappa
Clone Names 5D8
Calculated MW 164906 Da
Additional info
Gene ID 368
Other Names Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-E, ABCC6, ARA, MRP6
Target/Specificity ABCC6 (NP_001162, 831 a.a. ~ 930 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsABCC6 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

BACKGROUND

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

REFERENCES

Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. Zarbock R, et al. Clin Chim Acta, 2010 Oct 9. PMID 20541540.The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. de Boussac H, et al. J Biol Chem, 2010 Jul 23. PMID 20463007.Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. Costrop LM, et al. J Hum Genet, 2010 Feb. PMID 20075945.Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. Uitto J, et al. J Invest Dermatol, 2010 Mar. PMID 20032990.The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. K?bl?s G, et al. Genet Test Mol Biomarkers, 2010 Feb. PMID 19929409.

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