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>   首页   >   产品   >   一抗   >   其他   >   AEBP1 Antibody (monoclonal) (M01)   

AEBP1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant AEBP1.

     
  • 1 - AEBP1 Antibody (monoclonal) (M01) AT1062a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.96 KDa) .
  • 2 - AEBP1 Antibody (monoclonal) (M01) AT1062a
    Immunoperoxidase of monoclonal antibody to AEBP1 on formalin-fixed paraffin-embedded human adrenal gland. [antibody concentration 3 ug/ml]
  • 10 - AEBP1 Antibody (monoclonal) (M01) AT1062a
    Detection limit for recombinant GST tagged AEBP1 is approximately 0.3ng/ml as a capture antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC, E
Primary Accession Q8IUX7
Other Accession NM_001129
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG2a Kappa
Clone Names 1D2
Calculated MW 130929 Da
Additional info
Gene ID 165
Other Names Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein, AEBP1, ACLP
Target/Specificity AEBP1 (NP_001120, 912 a.a. ~ 1013 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsAEBP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

BACKGROUND

The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells.

REFERENCES

PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. Majdalawieh A, et al. Nucl Recept Signal, 2010 Apr 16. PMID 20419060.Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Schissel SL, et al. Am J Pathol, 2009 Mar. PMID 19179605.The role of AEBP1 in sex-specific diet-induced obesity. Zhang L, et al. Mol Med, 2005 Jan-Dec. PMID 16307171.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205.

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