AF1Q Antibody (monoclonal) (M01)

Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.

REFERENCES

1.MLLT11/AF1q is differentially expressed in maturing neurons during development.Yamada M, Clark J, Iulianella AGene Expr Patterns. 2014 May 16. pii: S1567-133X(14)00038-6. doi: 10.1016/j.gep.2014.05.001.2.AF1q: A Novel Mediator of Basal and 4-HPR-Induced Apoptosis in Ovarian Cancer Cells.Tiberio P, Cavadini E, Callari M, Daidone MG, Appierto V.PLoS One. 2012;7(6):e39968. Epub 2012 Jun 26.3.AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.Parcelier A, Maharzi N, Delord M, Robledo-Sarmiento M, Nelson E, Belakhdar-Mekid H, Pla M, Kuranda K, Parietti V, Goodhardt M, Legrand N, Bernstein ID, Gluckman JC, Sigaux F, Canque B.Blood. 2011 Aug 18;118(7):1784-96. Epub 2011 Jun 28.4.Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway.Co NN, Tsang WP, Wong TW, Cheung HH, Tsang TY, Kong SK, Kwok TT.Mol Cancer Ther. 2008 Oct;7(10):3160-8.5.Identification of the functional role of AF1Q in the progression of breast cancer.Chang XZ, Li DQ, Hou YF, Wu J, Lu JS, Di GH, Jin W, Ou ZL, Shen ZZ, Shao ZM.Breast Cancer Res Treat. 2008 Sep;111(1):65-78. Epub 2007 Oct 11.