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>   首页   >   产品   >   一抗   >   癌症   >   AGT Antibody (monoclonal) (M01)   

AGT Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant AGT.

     
  • 1 - AGT Antibody (monoclonal) (M01) AT1068a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
  • 1 - AGT Antibody (monoclonal) (M01) AT1068a
    AGT monoclonal antibody (M01), clone 1A10 Western Blot analysis of AGT expression in HepG2 ( (Cat # AT1068a )
  • 1 - AGT Antibody (monoclonal) (M01) AT1068a
    Western Blot analysis of AGT expression in transfected 293T cell line by AGT monoclonal antibody (M01), clone 1A10.

    Lane 1: AGT transfected lysate(53 KDa).
    Lane 2: Non-transfected lysate.
  • 10 - AGT Antibody (monoclonal) (M01) AT1068a
    Detection limit for recombinant GST tagged AGT is approximately 1ng/ml as a capture antibody.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P01019
Other Accession BC011519
Reactivity Human
Host mouse
Clonality monoclonal
Isotype IgG1 lambda
Clone Names 1A10
Calculated MW 53154 Da
Additional info
Gene ID 183
Other Names Angiotensinogen, Serpin A8, Angiotensin-1, Angiotensin 1-10, Angiotensin I, Ang I, Angiotensin-2, Angiotensin 1-8, Angiotensin II, Ang II, Angiotensin-3, Angiotensin 2-8, Angiotensin III, Ang III, Des-Asp[1]-angiotensin II, Angiotensin-4, Angiotensin 3-8, Angiotensin IV, Ang IV, Angiotensin 1-9, Angiotensin 1-7, Angiotensin 1-5, Angiotensin 1-4, AGT, SERPINA8
Target/Specificity AGT (AAH11519, 376 a.a. ~ 485 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsAGT Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas

BACKGROUND

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

REFERENCES

1.A haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice as compared to -217G.Jain S, Vinukonda G, Fiering SN, Kumar A.Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1849-57. Epub 2008 Oct 22.2.HNF-1 alpha plays an important role in IL-6 induced expression of the Human Angiotensinogen Gene.Jain S, Li Y, Patil S, Kumar A.Am J Physiol Cell Physiol. 2007 Jul;293(1):C401-10. Epub 2007 May 2.

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